NRP2 and PGF

Data Source:
HPRD (in vivo)

		NRP2	PGF
Description		neuropilin 2	placental growth factor
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Membrane	Extracellular Region Extracellular Space Membrane
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Viral Process Facial Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis
Pathways		Neurophilin interactions with VEGF and VEGFR NrCAM interactions	VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs			Aflibercept
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA	4 interacting genes: FLT1 NRP1 NRP2 VEGFA
Entrez ID		8828	5228
HPRD ID		03643	03076
Ensembl ID		ENSG00000118257	ENSG00000119630
Uniprot IDs		O60462 Q7Z3T9	G3XA84 P49763 Q53XY6 Q86TW6
PDB IDs		2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8	1FZV 1RV6
Enriched GO Terms of Interacting Partners?
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