ADAM15 and SH3RF3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ADAM15	SH3RF3
Description		ADAM metallopeptidase domain 15	SH3 domain containing ring finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Motile Cilium Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia	Apoptotic Process Positive Regulation Of JNK Cascade Protein Autoubiquitination
Pathways		Degradation of the extracellular matrix Invadopodia formation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)	Beard thickness ( 26926045) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Left-handedness ( 32989287) Monobrow thickness ( 26926045) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Rapid automised naming of digits ( 30741946) Scalp hair shape ( 26926045) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		34 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1	3 interacting genes: ADAM15 PAK2 RAC1
Entrez ID		8751	344558
HPRD ID		05674	19427
Ensembl ID		ENSG00000143537	ENSG00000172985
Uniprot IDs		Q13444	Q8TEJ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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