Wiki-Pi
About
Search
Browse
People
Updates
Search
TNFSF14 and ADIPOQ
Data Source:
BioGRID
(two hybrid)
TNFSF14
ADIPOQ
Description
TNF superfamily member 14
adiponectin, C1Q and collagen domain containing
Image
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Plasma Membrane
Integral Component Of Membrane
Extracellular Region
Collagen Trimer
Extracellular Space
Endoplasmic Reticulum
Cell Surface
Collagen-containing Extracellular Matrix
Molecular Function
Signaling Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Signaling Receptor Binding
Cytokine Activity
Hormone Activity
Extracellular Matrix Structural Constituent
Protein Binding
Sialic Acid Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Apoptotic Process
Immune Response
Signal Transduction
T Cell Costimulation
Tumor Necrosis Factor-mediated Signaling Pathway
T Cell Proliferation
T Cell Activation
T Cell Homeostasis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of NIK/NF-kappaB Signaling
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Glucose Metabolic Process
Generation Of Precursor Metabolites And Energy
Fatty Acid Beta-oxidation
Signal Transduction
Response To Nutrient
Circadian Rhythm
Response To Bacterium
Response To Sucrose
Response To Glucose
Positive Regulation Of Signal Transduction
Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Kinase A Signaling
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Regulation Of Glucose Metabolic Process
Response To Activity
Fatty Acid Oxidation
Negative Regulation Of Cell Migration
Negative Regulation Of Granulocyte Differentiation
Negative Regulation Of Protein Autophosphorylation
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-8 Production
Cellular Response To Insulin Stimulus
Positive Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Heterotypic Cell-cell Adhesion
Low-density Lipoprotein Particle Clearance
Response To Tumor Necrosis Factor
Cellular Response To Drug
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of MAP Kinase Activity
Response To Ethanol
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Macrophage Differentiation
Negative Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Glucose Import
Negative Regulation Of Hormone Secretion
Negative Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Phagocytosis
Negative Regulation Of Synaptic Transmission
Brown Fat Cell Differentiation
Response To Glucocorticoid
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Linoleic Acid
Detection Of Oxidative Stress
Cellular Response To CAMP
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Cellular Response To Epinephrine Stimulus
Protein Localization To Plasma Membrane
Negative Regulation Of Intracellular Protein Transport
Positive Regulation Of Lipid Transporter Activity
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Receptor Binding
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of Renal Albumin Absorption
Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Negative Regulation Of Metanephric Mesenchymal Cell Migration
Pathways
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
Adiponectin deficiency
GWAS
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Granulocyte percentage of myeloid white cells (
27863252
)
Monocyte count (
29403010
)
Monocyte percentage of white cells (
27863252
)
Multiple sclerosis (
31604244
24076602
21833088
)
Activated partial thromboplastin time (
22703881
)
Adiponectin levels (
21700879
26299439
20876611
20011104
22479202
20018283
19165155
24105470
)
Adiponectin levels (BMI-adjusted) (
26299439
)
Adiponectin levels in pregnancy (
28317342
)
Copper levels (
26025379
)
Interacting Genes
22 interacting genes:
ADAM33
ADIPOQ
APP
BMP10
CLDN11
CLDN19
CXCL9
JAGN1
LHFPL3
LTB
LTBR
MAL
OLFM4
PLLP
PTTG1IP
SEC22A
SEC23A
SYS1
TMEM11
TNFRSF14
TNFRSF6B
UPK2
61 interacting genes:
ADIPOR2
AMIGO1
AQP6
ASGR2
BCL2L13
BIK
BNIP3L
BSND
BTNL9
CAMLG
CCDC107
CD200R1
CD79A
CDH13
CLDN9
CLEC10A
CLEC2D
CNR2
COQ9
CPLX4
CREB3L1
CYBC1
ERP29
FAM209A
FASN
FCGR1A
FKBP7
FNDC9
GPR152
GPR42
HSD17B11
IFNGR2
KASH5
KCNK5
KEL
MFF
MFSD14B
MFSD6
MRM1
MS4A3
MUC1
NEMP1
PEX12
PROKR2
PVR
SCN3B
SGTA
SGTB
SIGLEC12
SLC16A2
SLC22A23
SLC35C2
SLC35E3
SYAP1
SYNE4
TMEM179B
TMEM237
TMEM35A
TMPRSS2
TNFSF14
TRIM35
Entrez ID
8740
9370
HPRD ID
05157
05671
Ensembl ID
ENSG00000125735
ENSG00000181092
Uniprot IDs
O43557
A8K660
B2R773
Q15848
PDB IDs
4EN0
4J6G
4KG8
4KGG
4KGQ
4RSU
4DOU
6U66
6U6N
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?