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RIPK1 and MAP3K8
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
RIPK1
MAP3K8
Description
receptor interacting serine/threonine kinase 1
mitogen-activated protein kinase kinase kinase 8
Image
GO Annotations
Cellular Component
Mitochondrion
Cytosol
Plasma Membrane
Endosome Membrane
Death-inducing Signaling Complex
Protein-containing Complex
Receptor Complex
Membrane Raft
Ripoptosome
Cytosol
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
Death Receptor Binding
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Death Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Cell Death
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Necrotic Cell Death
Viral Process
Protein Deubiquitination
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
Peptidyl-serine Autophosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Protein Catabolic Process
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Positive Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Positive Regulation Of Interleukin-6-mediated Signaling Pathway
T Cell Apoptotic Process
Necroptotic Process
Cellular Response To Hydrogen Peroxide
Regulation Of ATP:ADP Antiporter Activity
Cellular Response To Tumor Necrosis Factor
Death-inducing Signaling Complex Assembly
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Ripoptosome Assembly
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Hydrogen Peroxide-induced Cell Death
Amyloid Fibril Formation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Activation Of MAPKK Activity
Protein Phosphorylation
Cell Cycle
T Cell Costimulation
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Ub-specific processing proteases
Ovarian tumor domain proteases
Dimerization of procaspase-8
TNF signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IKK complex recruitment mediated by RIP1
Potential therapeutics for SARS
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Fostamatinib
Diseases
GWAS
Cerebral white matter volume (
31530798
)
Depressive symptoms x independent stressful life events interaction (1df test) (
30718454
)
Depressive symptoms x independent stressful life events interaction (2df test) (
30718454
)
Idiopathic osteonecrosis of the femoral head (
28000841
)
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
23128233
)
Systemising (
31508503
)
Ulcerative colitis (
28067908
)
Interacting Genes
45 interacting genes:
BIRC3
CASP8
CCDC50
CDC42BPB
CFLAR
CRADD
EGFR
FADD
FAS
HSP90AA1
IKBKB
IKBKE
IKBKG
ITCH
MAP3K14
MAP3K3
MAP3K8
MTDH
NFKB1
NUMBL
OTUD1
PELI1
PTK2
RIPK3
RNF11
RNF216
SQSTM1
TAX1BP1
TBK1
TICAM1
TNF
TNFAIP3
TNFRSF10A
TNFRSF10B
TNFRSF1A
TRADD
TRAF1
TRAF2
TRAF3
TRAF5
TRIM38
TRPC4AP
UBE2N
YOD1
ZFAND5
17 interacting genes:
ACY3
AKT1
BMPR2
CD40
CHUK
MAP2K1
MAP2K4
MAP3K14
NFKB1
NFKB2
REL
RELA
RIPK1
STIP1
TNIP2
TRAF2
TRAF6
Entrez ID
8737
1326
HPRD ID
04583
01863
Ensembl ID
ENSG00000137275
ENSG00000107968
Uniprot IDs
A0A024QZU0
Q13546
P41279
Q6FG25
PDB IDs
4ITH
4ITI
4ITJ
4NEU
5HX6
5TX5
5V7Z
6AC5
6C3E
6C4D
6HHO
6NW2
6NYH
6OCQ
6R5F
6RLN
4Y83
4Y85
5IU2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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