CDC23 and DCLK1

Data Source:
BioGRID (two hybrid)

		CDC23	DCLK1
Description		cell division cycle 23	doublecortin like kinase 1
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol	Integral Component Of Plasma Membrane Postsynaptic Density
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Neuron Migration Protein Phosphorylation Nervous System Development Central Nervous System Development Response To Virus Endosomal Transport Peptidyl-serine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Forebrain Development Intracellular Signal Transduction Axon Extension Neuron Projection Morphogenesis Dendrite Morphogenesis Negative Regulation Of Protein Localization To Nucleus
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)	Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595) Interleukin-10 levels ( 22205395) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Post bronchodilator FEV1 ( 26634245) Vertical cup-disc ratio ( 20548946 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		81 interacting genes: ANAPC10 ANAPC13 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BHLHB9 BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FBXO5 FOXN1 GORASP2 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KDM1A KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	3 interacting genes: APP CDC23 EFHC2
Entrez ID		8697	9201
HPRD ID		07221	09202
Ensembl ID		ENSG00000094880	ENSG00000133083
Uniprot IDs		Q9UJX2	B7Z5K4 O15075 Q5VZY9
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5	1MFW 1MG4 1UF0 5JZJ 5JZN 6KYQ 6KYR
Enriched GO Terms of Interacting Partners?
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