KRT37 and DES

Data Source:
BioGRID (two hybrid)

		KRT37	DES
Description		keratin 37	desmin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Extracellular Exosome	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril
	Molecular Function	Structural Molecule Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Keratinization Cornification	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Striated Muscle Contraction
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Squamous cell lung carcinoma ( 28604730)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)
Interacting Genes		41 interacting genes: AGXT AQP1 BCAS2 BFSP2 C21orf58 CCDC196 CLCNKA COL8A1 DES FAM110A FBXW5 GNG13 HAPLN2 HGS HOXA1 HSF4 KRT1 KRT3 KRT4 KRT6B KRT6C KRT71 KRT74 KRT75 KRT76 KRT81 KRT83 KRT85 KRT86 MTG1 NUFIP2 OIP5 OTX1 PIN1 PKN1 PSMA1 SMARCD1 SMARCE1 TBC1D21 TXLNB USHBP1	60 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GFAP GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 KRT75 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I VIM YES1 ZMYM5
Entrez ID		8688	1674
HPRD ID		05175	00514
Ensembl ID		ENSG00000108417	ENSG00000175084
Uniprot IDs		O76014	P17661 Q53SB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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