EIF3I and EIF3A

Data Source:
HPRD (in vivo)

		EIF3I	EIF3A
Description		eukaryotic translation initiation factor 3 subunit I	eukaryotic translation initiation factor 3 subunit A
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translational Initiation	Formation Of Cytoplasmic Translation Initiation Complex Translation Reinitiation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Plateletcrit ( 32888494)
Interacting Genes		12 interacting genes: EIF3A EIF3B EIF4G1 ERCC6 ESR1 EXOSC6 LIG4 METTL3 PAXIP1 SUMO4 TGFB1 TGFBR2	22 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF139 SRPK2 TFIP11 UBC UPF1 YWHAZ
Entrez ID		8668	8661
HPRD ID		04884	03618
Ensembl ID		ENSG00000084623	ENSG00000107581
Uniprot IDs		Q13347 Q5U0F4	Q14152
PDB IDs		6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09	3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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