EIF3H and LY6E

Data Source:
BioGRID (proximity labelling technology)

		EIF3H	LY6E
Description		eukaryotic translation initiation factor 3 subunit H	lymphocyte antigen 6 family member E
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Polysomal Ribosome Extracellular Exosome	Extracellular Region Plasma Membrane Anchored Component Of Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Metallopeptidase Activity Isopeptidase Activity Ubiquitinyl Hydrolase Activity	Protein Binding Acetylcholine Receptor Inhibitor Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Proteolysis Protein Phosphopantetheinylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Signaling Receptor Activity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 26965516 25990418 18372905 30529582 21761138 26151821 29471430 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: ABI1 ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS2 SORBS3 SPTBN1	6 interacting genes: CD247 FCGR2B MFSD6 TMEM140 TMEM19 TRARG1
Entrez ID		8667	4061
HPRD ID		04885	03227
Ensembl ID		ENSG00000147677	ENSG00000160932
Uniprot IDs		O15372 Q6IB98	Q16553
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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