SOCS1 and INSR

Data Source:
HPRD (two hybrid, in vitro)

		SOCS1	INSR
Description		suppressor of cytokine signaling 1	insulin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Nuclear Envelope Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola External Side Of Plasma Membrane Endosome Membrane Membrane Axon Nuclear Lumen Dendrite Membrane Neuronal Cell Body Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Protein Domain Specific Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Cargo Receptor Activity Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding PTB Domain Binding
	Biological Process	Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Regulation Of Activation Of Janus Kinase Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase Activity Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Amino Acid Stimulus	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Receptor-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Learning Memory Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Positive Regulation Of Cell Migration Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Positive Regulation Of Kinase Activity Glucose Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Dendritic Spine Maintenance Amyloid-beta Clearance Transport Across Blood-brain Barrier Neuron Projection Maintenance
Pathways		Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling
Drugs			Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate NN344 AT1391 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Chromic chloride Insulin degludec Fostamatinib Brigatinib Mecasermin rinfabate
Diseases			Rabson-Mendenhall syndrome Leprechaunism ; Donohue syndrome
GWAS		Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31959851 29273806) Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease ( 28067908) Crohn's disease and psoriasis ( 22482804) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 27399966 26502338)	Asthma (childhood onset) ( 27142222) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Chronotype (sMEQ score) ( 32579418) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diffusing capacity of carbon monoxide ( 30694715) Diverticular disease ( 30177863) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196 25673412) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Perceived unattractiveness to mosquitoes ( 28199695) Polycystic ovary syndrome ( 22885925) Pulse pressure ( 27618448 30578418) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Systolic blood pressure ( 28135244 27841878 28739976 27618448 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 28334899 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528 23263486)
Interacting Genes		47 interacting genes: AXL COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MET MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 TEC TEK TIRAP TRIM8 TYK2 VAV1 VAV2	86 interacting genes: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CCDC88A CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 DUSP18 DUSP19 ENPP1 ERBB2 FABP4 FRS2 GAB1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 MARCHF1 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF PTPRR RACK1 RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B STUB1 STYX SYNCRIP TEAD1 TRIM72 VAV1 VAV3 YWHAB
Entrez ID		8651	3643
HPRD ID		04669	00975
Ensembl ID		ENSG00000185338	ENSG00000171105
Uniprot IDs		O15524 Q4JHT5	P06213
PDB IDs			1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H 5KQV 5U1M 6HN4 6HN5 6PXV 6PXW 6SOF 6VEP 6VEQ
Enriched GO Terms of Interacting Partners?
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