KCNK5 and CYB5B

Data Source:
BioGRID (two hybrid)

		KCNK5	CYB5B
Description		potassium two pore domain channel subfamily K member 5	cytochrome b5 type B
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane	Mitochondrial Outer Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex
	Molecular Function	Voltage-gated Ion Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Leak Channel Activity	Protein Binding Enzyme Activator Activity Electron Transfer Activity Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity
	Biological Process	Potassium Ion Transport Excretion Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Electron Transport Chain Regulation Of Catalytic Activity
Pathways		Phase 4 - resting membrane potential	Phase I - Functionalization of compounds
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) HDL cholesterol levels ( 32203549) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)	Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 30993211 29403010)
Interacting Genes		29 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIPF6	48 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP FAM209A FAM210B FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MFSD14B MFSD4B MFSD5 MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A6 SLC16A2 SLC39A9 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B
Entrez ID		8645	80777
HPRD ID		04604	13106
Ensembl ID		ENSG00000164626	ENSG00000103018
Uniprot IDs		A0A024RD32 A0A0B6VPR3 O95279	O43169
PDB IDs			3NER
Enriched GO Terms of Interacting Partners?
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