AKR1C3 and MAGEA11

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AKR1C3	MAGEA11
Description		aldo-keto reductase family 1 member C3	MAGE family member A11
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Estradiol 17-beta-dehydrogenase Activity Retinol Dehydrogenase Activity Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Bile Acid Binding Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Delta4-3-oxosteroid 5beta-reductase Activity NADP-retinol Dehydrogenase Activity	Protein Binding
	Biological Process	Retinoid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Macromolecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of Prostaglandins (PG) and Thromboxanes (TX) RA biosynthesis pathway Retinoid metabolism and transport
Drugs		NADH Indomethacin Androstenedione Rutin Prostaglandin D2 Flufenamic acid Nicotinamide adenine dinucleotide phosphate 3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran
Diseases
GWAS		Epithelial ovarian cancer ( 31469419)
Interacting Genes		6 interacting genes: ACIN1 LRIF1 MAGEA11 SIAH2 UBE2W ZHX1	114 interacting genes: ACMSD ACSM2B ACTN1 AKR1C3 ALDH5A1 AR ARHGAP29 BCL2L11 BEX2 BIRC2 BRD1 C18orf54 C22orf39 CASP7 CAVIN3 CCDC105 CCDC106 CCDC14 CCDC146 CCDC185 CCDC27 CCNA2 CDC20B CDKN2B CEP76 CLUAP1 CORO1A COX7A2L CSNK2A1 CTTNBP2 DLGAP1 DNAJC10 DOCK10 ENOX2 EWSR1 FAM156A FAM161A FBXO46 GADD45GIP1 GCSH GNPDA1 HOXB5 IFI44 IL11 IL6ST ILF3 JADE3 KIAA0408 LMBR1L LNX1 MAPK3 MCRS1 MED28 MGME1 MLF1 MTA1 MXD3 MYOZ1 NCOA2 NDEL1 NDUFAF1 NDUFB9 NIF3L1 NOL4 NOS3 NSUN4 NTAQ1 OTUB2 PCBD2 PDE4B PHYH PIK3IP1 PIN4 PLCXD3 PNKD PNKP POLR1D PPIF PPM1K PRDX3 PRKRIP1 PSMF1 RADIL RANBP10 RBM23 REX1BD SH2D4A SNX20 SNX7 STAR SUCLA2 SUOX SUV39H2 TCEA2 TCEANC TCF25 TEX37 THEM5 TMEM123 TPM3 TRIM27 TRIM51 TRMT1 TXN2 UBE2D4 UBE3D USP20 UTP25 VTA1 WTAP ZBTB16 ZCCHC12 ZNF655 ZSWIM2
Entrez ID		8644	4110
HPRD ID		04911	02281
Ensembl ID		ENSG00000196139	ENSG00000185247
Uniprot IDs		A0A0A0MSS8 B4DKT3 P42330	G5E962 P43364
PDB IDs		1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WDT 4WDU 4WDW 4WDX 4WRH 4XVD 4XVE 4YVV 4YVX 4ZFC 5HNT 5HNU 6A7B 6F2U 6F78 6GXK 7C7F 7C7G 7C7H	6WJH
Enriched GO Terms of Interacting Partners?
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