PDLIM4 and FAM222B

Data Source:
BioGRID (two hybrid)

		PDLIM4	FAM222B
Description		PDZ and LIM domain 4	family with sequence similarity 222 member B
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Adherens Junction Z Disc Lamellipodium Early Endosome Membrane Early Endosome Lumen Filamentous Actin Recycling Endosome Lumen Dendritic Spine Postsynaptic Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Nucleoplasm
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Muscle Alpha-actinin Binding Alpha-actinin Binding	Protein Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Actin Cytoskeleton Reorganization Muscle Structure Development Excitatory Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Height ( 28552196) Inflammatory bowel disease ( 28067908 23128233) Mosquito bite size ( 28199695) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Estimated glomerular filtration rate reduction (30%) ( 30955190) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 27863252)
Interacting Genes		8 interacting genes: ABCA1 AMT FAM222B PTPN13 RBPMS SDCBP TRIP6 ZNF408	35 interacting genes: ANKRD10 BAG4 BANP BPIFA1 C10orf55 C19orf54 CDCA4 CNFN FAM168B FHL3 FOSB HYI INTS11 KRTAP11-1 KRTAP26-1 KRTAP3-1 LRRC61 OIP5 PDLIM4 PFDN5 PLA2G10 PRR20A PRR20B PRR20C PRR20D PRR20E RUNX1 SOHLH1 TRIP6 TSC1 TTLL12 UBQLN2 UFSP1 WWOX ZMYND12
Entrez ID		8572	55731
HPRD ID		04571	07693
Ensembl ID		ENSG00000131435	ENSG00000173065
Uniprot IDs		A0A0S2Z4N4 P50479	A0A024QZ60 B3KQ88 B3KTH5 B4DRX9 Q8WU58
PDB IDs		2EEG 2V1W 4Q2O
Enriched GO Terms of Interacting Partners?
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