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CAV1 and TNFRSF1B
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
CAV1
TNFRSF1B
Description
caveolin 1
TNF receptor superfamily member 1B
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Acrosomal Membrane
Caveolar Macromolecular Signaling Complex
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Lipid Droplet
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Focal Adhesion
Cilium
Cell Cortex
Membrane
Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Sarcolemma
Membrane Raft
Perinuclear Region Of Cytoplasm
Tumor Necrosis Factor Receptor Superfamily Complex
Extracellular Region
Nucleus
Plasma Membrane
Membrane
Integral Component Of Membrane
Specific Granule Membrane
Neuronal Cell Body
Varicosity
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Signaling Receptor Binding
Patched Binding
Protein Binding
Cholesterol Binding
Peptidase Activator Activity
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Ion Channel Binding
Protein-containing Complex Binding
Protein Heterodimerization Activity
Nitric-oxide Synthase Binding
ATPase Binding
Molecular Adaptor Activity
Inward Rectifier Potassium Channel Inhibitor Activity
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Tumor Necrosis Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Inactivation Of MAPK Activity
Angiogenesis
Vasculogenesis
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cytokine-mediated Signaling Pathway
Response To Ischemia
Regulation Of The Force Of Heart Contraction By Chemical Signal
Triglyceride Metabolic Process
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Regulation Of Smooth Muscle Contraction
Skeletal Muscle Tissue Development
Lactation
Protein Localization
Response To Bacterium
Positive Regulation Of Calcium Ion Transport Into Cytosol
Posttranscriptional Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Peptidase Activity
Protein Transport
Vesicle Organization
Receptor-mediated Endocytosis Of Virus By Host Cell
Regulation Of Fatty Acid Metabolic Process
Lipid Storage
Cell Differentiation
Regulation Of Blood Coagulation
Cholesterol Transport
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Receptor Internalization
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Maintenance Of Protein Location In Cell
Response To Progesterone
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Nitric Oxide Homeostasis
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Insulin Receptor Internalization
Vasoconstriction
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Cholesterol Homeostasis
Positive Regulation Of Catalytic Activity
Negative Regulation Of MAPK Cascade
Response To Estrogen
Protein Localization To Plasma Membrane Raft
Negative Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Vasoconstriction
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Pinocytosis
Leukocyte Migration
Regulation Of Nitric-oxide Synthase Activity
Negative Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cytosolic Calcium Ion Concentration
Response To Calcium Ion
Membrane Depolarization
Regulation Of Peptidase Activity
Calcium Ion Homeostasis
Mammary Gland Involution
Positive Regulation Of Cell Adhesion Molecule Production
Negative Regulation Of Necroptotic Process
Negative Regulation Of Protein Tyrosine Kinase Activity
Caveola Assembly
Cellular Response To Exogenous DsRNA
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Hyperoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
Basement Membrane Organization
Caveolin-mediated Endocytosis
Regulation Of Heart Rate By Cardiac Conduction
Angiotensin-activated Signaling Pathway Involved In Heart Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Apoptotic Signaling Pathway
Regulation Of Membrane Repolarization During Action Potential
Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Ruffle Assembly
Negative Regulation Of Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Basolateral Plasma Membrane
Positive Regulation Of Gap Junction Assembly
Negative Regulation Of Inward Rectifier Potassium Channel Activity
Beta-catenin Destruction Complex Disassembly
Receptor Internalization Involved In Canonical Wnt Signaling Pathway
Regulation Of Entry Of Bacterium Into Host Cell
Negative Regulation Of Anoikis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Cytokine Production Involved In Immune Response
Regulation Of T Cell Cytokine Production
Aortic Valve Development
Pulmonary Valve Development
Negative Regulation Of Extracellular Matrix Constituent Secretion
Inflammatory Response
Aging
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Cardiac Muscle Hypertrophy
Cytokine-mediated Signaling Pathway
Regulation Of Myelination
Positive Regulation Of Myelination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of T Cell Proliferation
Neutrophil Degranulation
Positive Regulation Of Oligodendrocyte Differentiation
RNA Destabilization
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Cell Death
Cellular Response To Lipopolysaccharide
Cellular Response To Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Regulation Of Neuroinflammatory Response
Negative Regulation Of Neuroinflammatory Response
Glial Cell-neuron Signaling
Negative Regulation Of Neuron Death
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Regulation Of RNA Biosynthetic Process
Pathways
Triglyceride catabolism
eNOS activation
NOSTRIN mediated eNOS trafficking
Basigin interactions
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
Extra-nuclear estrogen signaling
FOXO-mediated transcription of cell cycle genes
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Drugs
Tasonermin
Diseases
Congenital generalized lipodystrophy (CGL)
Graft-versus-host disease
GWAS
Atrial fibrillation (
28416822
30061737
29892015
22544366
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
20062063
25055868
)
Glaucoma (
30054594
)
Glaucoma (primary open-angle) (
29891935
25173105
20835238
)
Heart rate increase in response to exercise (
29497042
)
Heart rate response to recovery post exercise (10 sec) (
29497042
)
Heart rate response to recovery post exercise (20 sec) (
29497042
)
Heart rate response to recovery post exercise (30 sec) (
29497042
)
Heart rate response to recovery post exercise (40 sec) (
29497042
)
Heart rate response to recovery post exercise (50 sec) (
29497042
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Intraocular pressure (
29617998
25173106
28073927
29235454
)
Ischemic stroke (cardioembolic) (
29531354
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
P wave duration (
28794112
)
Platelet distribution width (
32888494
)
PR interval (
30679814
29127183
30046033
32439900
20062060
25035420
23139255
)
PR segment (
24850809
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
QRS duration (
30012220
)
QT interval (
24952745
29874175
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Asthma (
31959851
)
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Tuberculosis (
29036319
)
Urate levels (BMI interaction) (
25811787
)
Interacting Genes
84 interacting genes:
ABCB1
ABL1
AKAP1
APP
AR
BMX
BSG
BST1
BTK
CAV2
CD40
CSK
CSNK2A1
CSNK2A2
DAG1
DNM1
EDNRB
EGFR
ERBB2
ESR1
FLNA
FLOT2
FYN
GJA1
GJA3
GJB2
GLP1R
GNAI2
GRB7
GRK1
GRK2
GRK5
HRAS
HTR1F
IGF1R
IGFBP3
ILK
INSR
IRS1
KCNA3
KDR
LATS1
LRP1
MALL
MAPK1
MAPK3
MMP14
NEU3
NGFR
NOS2
NOS3
NTRK1
PDGFRA
PDGFRB
PLD1
PLD2
PPP1CA
PPP2CA
PRNP
PTEN
PTGS2
PTPN1
PTPN11
PTPN6
PTPRF
RAC1
RCVRN
RHOA
RHOC
S1PR1
SCP2
SNCA
SOS1
SRC
STOML3
STRN
STRN4
TEK
TGFBR1
TNFRSF1B
TRAF2
TRAF6
TRPC1
VAV2
21 interacting genes:
ADAM17
BMX
CAV1
CD14
CSNK1A1
CSNK1A1L
FANCD2
HIVEP3
KRT18
LTA
PKN1
STAT1
TDP2
TNF
TRAF1
TRAF2
TRAF3
TRAIP
TRIM37
UBQLN1
ZNF420
Entrez ID
857
7133
HPRD ID
03028
01862
Ensembl ID
ENSG00000105974
ENSG00000028137
Uniprot IDs
A0A024R757
A9XTE5
Q03135
Q2TNI1
Q59E85
Q7Z4F3
P20333
PDB IDs
1CA9
3ALQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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