YARS1 and ELANE

Data Source:
HPRD (in vitro)

		YARS1	ELANE
Description		tyrosyl-tRNA synthetase 1	elastase, neutrophil expressed
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Nuclear Body	Extracellular Region Extracellular Space Cytoplasm Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	TRNA Binding RNA Binding Tyrosine-tRNA Ligase Activity Interleukin-8 Receptor Binding Protein Binding ATP Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Tyrosyl-tRNA Aminoacylation Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Antimicrobial Humoral Response Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Cytosolic tRNA aminoacylation	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade
Drugs		Tyrosine Beta-(2-Naphthyl)-Alanine Resveratrol Tyrosinal N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE p-Benzoyl-L-phenylalanine 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE	Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS			Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: CDC42 ELANE ESR1 REL	30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		8565	1991
HPRD ID		09153	00554
Ensembl ID		ENSG00000134684	ENSG00000197561
Uniprot IDs		A0A0S2Z4R1 P54577	P08246
PDB IDs		1N3L 1NTG 1Q11 4Q93 4QBT 5THH 5THL	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK
Enriched GO Terms of Interacting Partners?
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