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CDC14B and PSMB1
Data Source:
BioGRID
(two hybrid)
CDC14B
PSMB1
Description
cell division cycle 14B
proteasome 20S subunit beta 1
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Mitotic Spindle
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
DNA Repair
Protein Dephosphorylation
Regulation Of Exit From Mitosis
G2 DNA Damage Checkpoint
Positive Regulation Of Cytokinesis
Peptidyl-tyrosine Dephosphorylation
Cilium Assembly
Mitotic Cell Cycle Arrest
Signal Transduction Involved In G2 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin Protein Ligase Activity
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
MAPK6/MAPK4 signaling
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Bortezomib
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Carfilzomib
Diseases
GWAS
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Household income (
31844048
)
Intelligence (MTAG) (
29326435
)
Peginterferon alfa-2a treatment response in chronic hepatitis B infection (
30972912
)
Blood protein levels (
30072576
)
Type 1 diabetes (
21980299
)
Interacting Genes
19 interacting genes:
BCL10
BUB1
CCND1
CDKN2A
DLC1
MCC
MFAP1
MLH3
MSH2
MTDH
PRKAB2
PSMB1
SIRT2
SKP2
SMAD4
SPANXN2
STK11
TP53
ZNF696
105 interacting genes:
AGR2
AHSP
ARNT2
BEND7
BIRC7
BPIFA1
CAMK2G
CCM2L
CDC14B
CDC42
CDKN1B
CLPP
COG6
CTAG1A
CTAG1B
CYTH4
DCP2
DDI1
EXOSC6
FAM136A
FAM50B
FANCG
GADD45GIP1
GEMIN2
GEMIN4
GPBP1
GRIPAP1
GTPBP2
HMG20A
HOXA1
IMPACT
INSIG2
JAKMIP1
KATNBL1
KHDC4
KIFC3
KRT13
KRT15
KRT31
KRT34
KRT36
KRT40
KRTAP15-1
KRTAP19-1
KRTAP19-7
KRTAP7-1
LCE1C
LCE1F
LDB2
LENG1
LHX3
LIN7B
LMO1
LZTFL1
MAPRE3
MKRN3
MLKL
MRNIP
MTUS2
NANOS3
NME4
OIP5
OTUD7B
PIP4K2B
PLEKHG4
PLK1
POMP
PSEN1
PSMA1
PSMB3
PSMB4
PSMB5
PSMB7
PSMG3
PYCR3
RIPPLY3
RNF8
RPRD1B
RWDD2A
RYBP
SCARA5
SERPINB2
SH3GL1
SMAD3
SMARCB1
STMN2
TFPT
THAP6
TLE5
TOLLIP
TRAF1
TRAF2
TRIM23
TRIM27
TRIM39
TTC33
UBASH3B
VAX1
XPA
ZBTB32
ZNF177
ZNF438
ZNF559-ZNF177
ZNF688
ZNF774
Entrez ID
8555
5689
HPRD ID
04615
03603
Ensembl ID
ENSG00000081377
ENSG00000008018
Uniprot IDs
O60729
A0A140VK45
P20618
PDB IDs
1OHC
1OHD
1OHE
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5L5B
5L5D
5L5E
5L5F
5L5H
5L5I
5L5J
5L5O
5L5P
5L5Q
5L5R
5L5S
5L5T
5L5U
5L5V
5L5W
5L5X
5L5Y
5L5Z
5L60
5L61
5L62
5L63
5L64
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M2B
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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