KRTAP2-4 and CREB5

Data Source:
BioGRID (two hybrid)

		KRTAP2-4	CREB5
Description		keratin associated protein 2-4	cAMP responsive element binding protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Chromatin Nucleus Extracellular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Keratinization	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated
Pathways		Keratinization Keratinization
Drugs
Diseases
GWAS			Adolescent idiopathic scoliosis ( 31417091) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Anxiety in major depressive disorder ( 24047446) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 30061737 29892015) Attention deficit hyperactivity disorder ( 18839057) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Crohn's disease ( 23128233) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pre-treatment viral load in HIV-1 infection ( 31219150) Pulse pressure ( 27841878 30578418) Serum thyroid-stimulating hormone levels ( 25436638) Smoking behaviour (cigarettes smoked per day) ( 31217584) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 29403010 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		95 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CBX2 CHIC2 CNNM3 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP10-5 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 PTPMT1 RHBDL1 RPS28 SDC3 SHFL SPATA3 SPRED2 TFAP2D TMEM190 TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792	132 interacting genes: ADAMTSL4 AJUBA AKAP8L ALPP ANAPC11 ATF2 BATF3 CDPF1 CERCAM CIB4 CNFN COL8A1 CYP21A2 CYSRT1 EFEMP2 FBLN1 FHL3 FOS FOSB FOSL1 FOSL2 FRS3 FST HOXA1 HSD3B7 ID3 IGFBP6 INTS11 JDP2 JUN KIFC3 KPRP KRT15 KRT31 KRT40 KRT83 KRT85 KRT86 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1C LCE2A LCE2C LCE4A LCE5A LGALS13 LITAF LMX1B MDFI MGAT5B MLLT6 MMADHC MTUS2 NADSYN1 NBPF19 NOTCH2NLA PCSK5 PLA2G10 PRDM14 PRR22 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS20 RIMBP3 RNF144B RNF208 SIVA1 SNAPC5 SPATA12 SPOP SPOPL SPRED1 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D TP53BP1 TRAF2 TRIM23 TRIM27 TRIM42 TRIP6 TSGA10 TSPAN4 TSR2 UFSP1 UNKL WWOX ZMAT5 ZNF330
Entrez ID		85294	9586
HPRD ID		13936	09896
Ensembl ID		ENSG00000213417	ENSG00000146592
Uniprot IDs		P0C7H8 Q9BYR9	Q02930
PDB IDs
Enriched GO Terms of Interacting Partners?
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