TMEM128 and GJA1

Data Source:
BioGRID (two hybrid)

		TMEM128	GJA1
Description		transmembrane protein 128	gap junction protein alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Golgi Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexin Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Cell Junction Golgi-associated Vesicle Membrane Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Membrane Raft Tight Junction
	Molecular Function	Molecular_function Protein Binding	Gap Junction Channel Activity Protein Binding Beta-catenin Binding Ion Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Tubulin Binding SH3 Domain Binding PDZ Domain Binding Glutathione Transmembrane Transporter Activity Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Disordered Domain Specific Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Biological_process	Establishment Of Mitotic Spindle Orientation Negative Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Response To Ischemia Positive Regulation Of Glomerular Filtration Endothelium Development Apoptotic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Spermatogenesis Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Glutamate Secretion ATP Transport Gap Junction Assembly Regulation Of Transmembrane Transporter Activity Negative Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Gonadotropin Secretion Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Ion Transmembrane Transport Response To Fluid Shear Stress Cellular Protein Localization Glutathione Transmembrane Transport Maintenance Of Protein Localization In Endoplasmic Reticulum Maintenance Of Blood-brain Barrier Xenobiotic Transport Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Positive Regulation Of Protein Catabolic Process Positive Regulation Of Vasoconstriction Decidualization Bone Remodeling Neuron Projection Morphogenesis Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cold-induced Thermogenesis Export Across Plasma Membrane Negative Regulation Of Trophoblast Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Mesodermal Cell Differentiation Epididymis Development Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Stem Cell Proliferation Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Behavioral Fear Response
Pathways			Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction assembly Gap junction degradation Regulation of gap junction activity Regulation of gap junction activity Formation of annular gap junctions
Drugs			Carvedilol
Diseases			Syndactyly Deafness, autosomal recessive Oculodentodigital dysplasia
GWAS		Glomerular filtration rate ( 24351856)	Atrial fibrillation ( 28416818 28416822 29892015) Disease progression in age-related macular degeneration ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Focal epilepsy (with hippocampal sclerosis) ( 30531953) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heart rate ( 23583979) Heel bone mineral density ( 30598549) Migraine ( 27322543) Peak creatinine levels in vancomycin therapy ( 26030142) PR interval ( 32439900) Protein quantitative trait loci ( 18464913) Pulse pressure ( 28135244 27841878) Resting heart rate ( 29769521 23183192 27798624 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Tendinopathy ( 31615970) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		61 interacting genes: AQP6 ARL13B BCL2L13 BEST2 CD40 CD53 CD79A CLDN5 CLDN7 CLN8 CREB3L1 CYB561 CYBC1 ELOVL4 ERGIC3 FAM209A GAD2 GJA1 GJA8 GJB5 GORAB GPR152 GPX8 HSD17B11 IER3IP1 IL3RA JAGN1 KCNK5 LEUTX LHFPL2 LHFPL5 LMNA MAPK8IP2 MFF MFSD5 MRPS18B MTERF1 MTIF3 MUC1 REEP4 RETREG3 SCN3B SEC11C SHISAL1 SLC10A6 SLC18A1 SLC1A3 SLC26A6 SLC34A2 SLC7A14 SSMEM1 STX1A TMEM106A TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 TMX2 ZDHHC15 ZFYVE27	26 interacting genes: AKT1 CAV1 CCN3 CNST CREB3 CSK CSNK1D GJA3 GJA5 HTR2C MAPK1 MAPK3 MAPK7 NINJ2 PLPP4 PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1 TMEM128 TMEM86B UBQLN4
Entrez ID		85013	2697
HPRD ID		17483	00414
Ensembl ID		ENSG00000132406	ENSG00000152661
Uniprot IDs		B7Z3K1 Q5BJH2	A0A654IBU3 P17302
PDB IDs			2LL2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?