UBASH3B and RNF216

Data Source:
BioGRID (two hybrid)

		UBASH3B	RNF216
Description		ubiquitin associated and SH3 domain containing B	ring finger protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Negative Regulation Of Signal Transduction Peptidyl-tyrosine Dephosphorylation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation	Apoptotic Process Viral Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways			Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 24097068 25961943 20686565) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Serum immune biomarker levels ( 32066700) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)
Interacting Genes		51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		84959	54476
HPRD ID		16463	15550
Ensembl ID		ENSG00000154127	ENSG00000011275
Uniprot IDs		Q8TF42	A8K8N1 Q9NWF9
PDB IDs		2CPW 2E5K 5VR6 5W5G
Enriched GO Terms of Interacting Partners?
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