SYTL1 and NCF1

Data Source:
BioGRID (pull down)

		SYTL1	NCF1
Description		synaptotagmin like 1	neutrophil cytosolic factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Plasma Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle	Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Protein Binding Neurexin Family Protein Binding	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity
	Biological Process	Intracellular Protein Transport Exocytosis	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade
Pathways		TBC/RABGAPs	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Interacting Genes		7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A	28 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		84958	653361
HPRD ID		12156
Ensembl ID		ENSG00000142765	ENSG00000158517
Uniprot IDs		Q8IYJ3	P14598
PDB IDs			1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?
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