PPM1D and RHOBTB2

Data Source:
BioGRID (two hybrid)

		PPM1D	RHOBTB2
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	Rho related BTB domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Transcriptional regulation by RUNX2	RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Alzheimer's disease progression score ( 29860282) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)
Interacting Genes		24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11
Entrez ID		8493	23221
HPRD ID		05482	06300
Ensembl ID		ENSG00000170836	ENSG00000008853
Uniprot IDs		A0A0S2Z4M2 O15297	Q9BYZ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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