LINC00839 and YAP1

Data Source:
BioGRID (unspecified method)

		LINC00839	YAP1
Description		long intergenic non-protein coding RNA 839	Yes1 associated transcriptional regulator
Image		No pdb structure
GO Annotations	Cellular Component		Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TEAD-YAP Complex
	Molecular Function		Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Trophectodermal Cell Differentiation Tissue Homeostasis Heart Process Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Hippo Signaling Wound Healing Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Progesterone Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Contact Inhibition Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Development Cardiac Muscle Tissue Regeneration Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS			Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 30566500 26416764) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		82 interacting genes: ADAMTS15 AKAP13 ALDH16A1 APOL3 BFSP1 CALM1 CC2D1B CCDC168 CCDC93 CDC16 CEP192 CEP295NL CHPF CIZ1 CLGN CLPTM1 COPB1 DNAH10 DPEP3 EFL1 EID2 EMX1 FAAP100 FAM13B FBXL5 HAPLN4 IQCN IRX4 JAKMIP2 KLK14 KRT1 KRT6B L1CAM MEX3A MEX3B MEX3C MEX3D MICAL2 MYO7A NDUFA2 NOC4L NOTCH3 NVL OS9 P4HB PABPN1 PALM3 PARP6 PHACTR1 PKD1L2 PLOD3 PNPLA3 POMT2 PRSS1 PRSS3 PTBP1 PTEN PTPRA QSOX2 RAPGEF6 RIF1 RPLP2 RPTOR RYR2 SEMA4D SEPTIN12 SEPTIN9 SERHL2 SLC7A14 SOWAHB SREBF2 SYNE1 SYNE3 TAS1R3 TCF24 TMC4 TRO UBE2S VANGL1 YAP1 YIPF1 ZFPL1	33 interacting genes: ABL1 AKT1 ENAH ERBB4 GAS5 HNRNPU KIF5A LINC00839 NFE2 OTUD1 PRRG2 PTCH1 PTEN PTPN21 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP73 WBP1 WBP2 YWHAG YWHAQ YWHAZ
Entrez ID		84856	10413
HPRD ID		17516	09424
Ensembl ID		ENSG00000185904	ENSG00000137693
Uniprot IDs			A0A024R3E4 K0KVU2 P46937 Q86T74
PDB IDs			1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X
Enriched GO Terms of Interacting Partners?
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