CASR and HIF1A

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CASR	HIF1A
Description		calcium sensing receptor	hypoxia inducible factor 1 subunit alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Axon Terminus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body Nuclear Speck Motile Cilium Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Axon Cytoplasm
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Protein Homodimerization Activity Ion Channel Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding
	Biological Process	Ossification Response To Ischemia Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Positive Regulation Of ATPase Activity Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Cellular Response To Peptide Chloride Transmembrane Transport	Response To Reactive Oxygen Species Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cytokine Production Involved In Inflammatory Response Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Signal Transduction Lactation Visual Learning Response To Iron Ion Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Response To Muscle Activity Positive Regulation Of Macroautophagy Protein Ubiquitination Protein Deubiquitination Cytokine-mediated Signaling Pathway Axonal Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Post-translational Protein Modification Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Iris Morphogenesis Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Hypoxia-inducible Factor-1alpha Signaling Pathway Cellular Response To Virus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein Neddylation Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha NOTCH1 Intracellular Domain Regulates Transcription Circadian Clock Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation
Drugs		Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate	Carvedilol Hydralazine 2-Methoxyestradiol ENMD-1198 PX-478 FG-2216
Diseases		Bartter syndrome
GWAS		Calcium levels ( 20661308 25972035 25886283 24068962 29403010 20705733) Cardiac Troponin-T levels ( 23247143) Clinical laboratory measurements ( 27897004) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 32499647 30718926)
Interacting Genes		11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL	125 interacting genes: AKT1 APEX1 AR ARNT ARNT2 ARNTL ATM AURKA BNIP3 CASR CCND2 CDC34 CDK4 CDK6 CDKN2A CDKN2B CITED2 COPS5 CREB3L1 CREBBP CSNK1D CSNK2A1 CTNNB1 DAP3 E2F7 EAF2 EGLN1 EGLN2 EGLN3 EIF5A2 EP300 EPHA2 EPO ESRRA ESRRB ESRRG ETV4 F12 FGFR4 FZR1 GATA3 GLIS2 HDAC1 HDAC2 HDAC3 HDAC5 HIF1A-AS2 HIF1AN HIF3A HNF4A HSP90AA1 IKBKG ISG15 JUN KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LATS2 LINC01139 LRRK2 MAFG MAFK MAP2K3 MAP2K5 MAPK1 MAPK3 MAX MCL1 MCM7 MDM2 MTA1 MYC NAA10 NAA11 NBN NCOA1 NCOA2 NDN NEDD8 NF2 NQO1 NR4A1 OS9 PER1 PGK1 PKM PLD1 PLD2 PLK3 PRKACA PSMA7 PTBP1 PTK6 RACGAP1 RACK1 RB1 RORA RUNX2 RWDD3 SAT1 SEPTIN9 SIRT2 SMAD3 SP1 SSX4 STAT3 STK11 STUB1 SUCO SUMO1 TEAD2 TP53 TSGA10 UBE2D1 UBE2I USP19 USP20 USP28 USP7 VEGFA VHL VHLL ZC3H12A
Entrez ID		846	3091
HPRD ID		03122	04517
Ensembl ID		ENSG00000036828	ENSG00000100644
Uniprot IDs		P41180	D0VY79 Q16665
PDB IDs		5FBH 5FBK 5K5S 5K5T	1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS 6GFX 6GMR
Enriched GO Terms of Interacting Partners?
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