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CUL1 and PPP1CA
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
CUL1
PPP1CA
Description
cullin 1
protein phosphatase 1 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Ribonucleoprotein Complex Binding
Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Monoubiquitination
Cellular Iron Ion Homeostasis
Cell Population Proliferation
Animal Organ Morphogenesis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Protein Dephosphorylation
Cell Cycle
Response To Lead Ion
Viral Process
Dephosphorylation
Lung Development
Negative Regulation Of Protein Binding
Circadian Regulation Of Gene Expression
Peptidyl-threonine Dephosphorylation
Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Branching Morphogenesis Of An Epithelial Tube
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Peptidyl-serine Dephosphorylation
Cell-cell Adhesion
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Circadian Clock
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Interacting Genes
56 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CDKN1B
CENPE
CENPW
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
E2F1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
GHR
GPS1
HIPK2
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
161 interacting genes:
AATK
AKAP1
AKAP11
AKAP9
APAF1
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDH1
CEP126
CEP170
CKB
CLCN2
CLOCK
CLTC
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MIIP
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R16B
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R32
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RIF1
RORC
RPRD2
SFPQ
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TUSC3
UBE2Z
ULK1
VDR
WBP11
WDR82
WWTR1
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
Entrez ID
8454
5499
HPRD ID
04389
15942
Ensembl ID
ENSG00000055130
ENSG00000172531
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
A0A140VJS9
P62136
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
Enriched GO Terms of Interacting Partners
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