PCBD2 and CENPK

Data Source:
BioGRID (two hybrid)

		PCBD2	CENPK
Description		pterin-4 alpha-carbinolamine dehydratase 2	centromere protein K
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Condensed Nuclear Chromosome Inner Kinetochore Nucleoplasm Cytosol
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Protein Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated	Mitotic Sister Chromatid Segregation CENP-A Containing Nucleosome Assembly Kinetochore Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		40 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	11 interacting genes: AP1G2 CENPH HSPB1 MRFAP1L1 PCBD2 PEX14 RTN4IP1 SOX6 TRIM55 TRIM63 WASHC3
Entrez ID		84105	64105
HPRD ID		17824	13323
Ensembl ID		ENSG00000132570	ENSG00000123219
Uniprot IDs		Q9H0N5	D6RHD3 Q9BS16
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?
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