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SPOP and HMGCS1
Data Source:
BioGRID
(two hybrid)
SPOP
HMGCS1
Description
speckle type BTB/POZ protein
3-hydroxy-3-methylglutaryl-CoA synthase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Cul3-RING Ubiquitin Ligase Complex
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
Hydroxymethylglutaryl-CoA Synthase Activity
Drug Binding
Isomerase Activity
Protein Homodimerization Activity
Organic Acid Binding
Biological Process
Protein Polyubiquitination
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Liver Development
Acetyl-CoA Metabolic Process
Lipid Metabolic Process
Cholesterol Biosynthetic Process
Brain Development
Male Gonad Development
Response To Low Light Intensity Stimulus
Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway
Response To Purine-containing Compound
Regulation Of Lipid Metabolic Process
Response To Vitamin E
Response To Drug
Regulation Of Cholesterol Biosynthetic Process
Response To Tellurium Ion
Cellular Response To Follicle-stimulating Hormone Stimulus
Cellular Response To Cholesterol
Cellular Response To Low-density Lipoprotein Particle Stimulus
Pathways
Hedgehog 'on' state
Cholesterol biosynthesis
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Drugs
(7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid
Diseases
GWAS
Prostate cancer (
23535732
)
Interacting Genes
66 interacting genes:
AEN
AMOTL2
AR
BRD2
BRD3
BRMS1
CACUL1
CBX4
CCNE1
CDK4
CHAF1A
CHD3
CREB5
CTDSPL2
CUL3
DDIT3
DHX15
DPPA2
EGLN2
ERF
ERG
FAF1
GATAD2A
GCC1
GCC2
GIT2
GLI2
GMEB1
HCST
HMGCS1
INF2
IRF1
KPNA5
LRCH4
MACROH2A1
MRE11
MYD88
NANOG
NCOA3
NUDCD3
PDX1
PIAS1
PIAS3
RANBP9
RBFOX2
RBPJ
RPRD2
RTN3
RXRB
SETD2
SRRM1
SUMO1
TCOF1
TOPORS
TRAF1
TRAF6
UBE2D1
UBE2D2
UBE2E3
UBE2I
UBE2L3
VPS9D1-AS1
YWHAG
ZBTB16
ZCCHC12
ZMYND8
1 interacting genes:
SPOP
Entrez ID
8405
3157
HPRD ID
16004
07515
Ensembl ID
ENSG00000121067
ENSG00000112972
Uniprot IDs
O43791
A0A024R059
Q01581
PDB IDs
2CR2
3HQH
3HQI
3HQL
3HQM
3HSV
3HTM
3HU6
3IVB
3IVQ
3IVV
4EOZ
4HS2
4J8Z
4O1V
6F8F
6F8G
6I41
6I5P
6I68
6I7A
2P8U
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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