BRIP1 and PECAM1

Data Source:
BioGRID (affinity chromatography technology)

		BRIP1	PECAM1
Description		BRCA1 interacting protein C-terminal helicase 1	platelet and endothelial cell adhesion molecule 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	DNA Damage Checkpoint DNA Replication Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination	Positive Regulation Of Protein Phosphorylation Platelet Degranulation Phagocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Cell Recognition Extracellular Matrix Organization Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Neutrophil Degranulation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Diapedesis Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Glomerular Endothelium Development Neutrophil Extravasation Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways		Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation
Drugs
Diseases		Fanconi anemia
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Coronary artery disease ( 32469254 29212778 33020668) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		10 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HSD17B14 RPA1 SIRT1 TOPBP1	22 interacting genes: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		83990	5175
HPRD ID		05797	01425
Ensembl ID		ENSG00000136492	ENSG00000261371
Uniprot IDs		Q9BX63	P16284
PDB IDs		1T15 1T29 3AL3	2KY5 5C14 5GNI
Enriched GO Terms of Interacting Partners?
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