RHNO1 and TOPBP1

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down)

		RHNO1	TOPBP1
Description		RAD9-HUS1-RAD1 interacting nuclear orphan 1	DNA topoisomerase II binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	DNA Damage Checkpoint Recombinational Repair DNA Replication Cell Cycle Cellular Response To UV Positive Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
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Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Iron status biomarkers ( 19084217)
Interacting Genes		12 interacting genes: BANP CYSRT1 GOLGA2 HUS1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LZTS2 RAD1 RAD9A TFIP11 TOPBP1	32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17
Entrez ID		83695	11073
HPRD ID		17487	09678
Ensembl ID		ENSG00000171792	ENSG00000163781
Uniprot IDs		Q9BSD3	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		6J8Y	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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