MXD3 and SMC3

Data Source:
BioGRID (two hybrid, pull down)

		MXD3	SMC3
Description		MAX dimerization protein 3	structural maintenance of chromosomes 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways			Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Activated partial thromboplastin time ( 22703881) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Diastolic blood pressure ( 30224653) Lymphocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum uric acid levels ( 30993211) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: CYSRT1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP3-3 MAGEA11 MAX NBPF19 NOTCH2NLA NUP62 SMC3 TFIP11	18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		83463	9126
HPRD ID		14791	05829
Ensembl ID		ENSG00000213347	ENSG00000108055
Uniprot IDs		A0A024R7S0 Q9BW11	Q9UQE7
PDB IDs			6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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