H2BC15 and BCCIP

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		H2BC15	BCCIP
Description		H2B clustered histone 15	BRCA2 and CDKN1A interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Centrosome Centriole Cytosol Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Spindle Pole
	Molecular Function	DNA Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Kinase Regulator Activity
	Biological Process	Nucleosome Assembly Protein Ubiquitination	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization DNA Repair Mitotic Spindle Organization Microtubule Anchoring Neuroendocrine Cell Differentiation Mitotic Spindle Assembly
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		19 interacting genes: BCCIP EWSR1 FAM133A FAM9A H1-7 H2AB2 H2AB3 H2AC18 H2AC19 H2AC4 H2AC8 MACROH2A1 MACROH2A2 NKAPD1 PRR13 RPL22 SPANXN2 SREK1IP1 TSPYL2	26 interacting genes: ABCB1 BARD1 BRCA2 CAPZB CCDC33 CDC42 CDKN1A CENPJ CSNK2B FCF1 H2BC15 ITSN2 MRPS9 PDGFB PTN PTPRM RAD51 RALY RPL23 RPL38 SRC TENT5A TP53 YY1 ZNF138 ZNF19
Entrez ID		8341	56647
HPRD ID		11899	16542
Ensembl ID		ENSG00000233822	ENSG00000107949
Uniprot IDs		A0A024RCJ9 Q99877	Q9P287
PDB IDs
Enriched GO Terms of Interacting Partners?
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