EOMES and OTP

Data Source:
BioGRID (two hybrid)

		EOMES	OTP
Description		eomesodermin	orthopedia homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Fibrillar Center Nucleoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Cell Fate Specification Endodermal Cell Fate Specification Heart Looping Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Regulation Of Transcription By RNA Polymerase II Brain Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Forebrain Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Neuron Differentiation
Pathways
Drugs
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankylosing spondylitis ( 23749187) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414) Diastolic blood pressure ( 27841878) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Hodgkin's lymphoma ( 24149102) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Mean arterial pressure ( 29403010) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088) PR interval ( 30046033) Pulse pressure ( 29403010) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966) Systolic blood pressure ( 29403010) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: OTP PFDN1	8 interacting genes: BEX1 CCL21 CDK6 CPNE7 EOMES PDE6D SLC12A7 TPGS2
Entrez ID		8320	23440
HPRD ID		07054	05166
Ensembl ID		ENSG00000163508	ENSG00000171540
Uniprot IDs		B7Z4K0 O95936	Q5XKR4
PDB IDs
Enriched GO Terms of Interacting Partners?
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