BAP1 and H2AC4

Data Source:
BioGRID (enzymatic study, enzymatic study)

		BAP1	H2AC4
Description		BRCA1 associated protein 1	H2A clustered histone 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Response To Inorganic Substance Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Chromatin Silencing Negative Regulation Of Cell Population Proliferation
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		27 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	25 interacting genes: BAP1 BMI1 BRCA1 CDK1 CDK2 EIF2AK2 EP300 FANCD2 H2BC15 H2BC3 KAT2B KAT5 MAP4K1 MYB PRMT5 PSMD4 PTEN RNF168 RNF2 RPL6 TRIM37 UBE2D3 UHRF1 USP16 USP51
Entrez ID		8314	8335
HPRD ID		04366	09105
Ensembl ID		ENSG00000163930	ENSG00000278463
Uniprot IDs		A0A024R305 F8W6N3 Q92560	P04908 Q08AJ9
PDB IDs			2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6JXD 6KE9 6KXV 6L49 6L4A 6L9H 6LA8 6LA9 6LE9 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6V92 6YOV 7C0M 7CCQ 7CCR
Enriched GO Terms of Interacting Partners?
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