USP9X and ALDH1A3

Data Source:
BioGRID (enzymatic study)

		USP9X	ALDH1A3
Description		ubiquitin specific peptidase 9 X-linked	aldehyde dehydrogenase 1 family member A3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Retinal Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Homodimerization Activity Thyroid Hormone Binding NAD+ Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Protein Targeting To Peroxisome Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Cell Migration Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Regulation Of Circadian Rhythm Cellular Protein Metabolic Process Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation	Optic Cup Morphogenesis Involved In Camera-type Eye Development Retinoic Acid Biosynthetic Process Locomotory Behavior Nucleus Accumbens Development Embryonic Camera-type Eye Development Inner Ear Morphogenesis Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Embryonic Eye Morphogenesis Neuromuscular Process Controlling Balance Protein Homotetramerization Righting Reflex Olfactory Pit Development Face Development Harderian Gland Development
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation	RA biosynthesis pathway
Drugs			NADH Vitamin A
Diseases
GWAS		Migraine ( 27322543)	Chin dimples ( 27182965) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		25 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RNF115 SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	1 interacting genes: USP9X
Entrez ID		8239	220
HPRD ID		02091	02713
Ensembl ID		ENSG00000124486	ENSG00000184254
Uniprot IDs		Q6P468 Q86X58 Q93008	A0A024RC95 H0Y2X5 P47895 Q7Z3A2
PDB IDs		5VBD 5WCH	5FHZ 6S6W
Enriched GO Terms of Interacting Partners?
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