NECTIN4 and NECTIN1

Data Source:
HPRD (in vitro)

		NECTIN4	NECTIN1
Description		nectin cell adhesion molecule 4	nectin cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Adherens Junction Membrane Integral Component Of Membrane Dendrite Growth Cone Membrane Intracellular Membrane-bounded Organelle Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Virion Attachment To Host Cell Adherens Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cell-cell Adhesion Protein Localization To Cell Junction
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		Enfortumab vedotin
Diseases		Ectodermal dysplasia-syndactyly syndrome (EDSS)	Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS
Interacting Genes		6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT	10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR
Entrez ID		81607	5818
HPRD ID		17934	07200
Ensembl ID		ENSG00000143217	ENSG00000110400
Uniprot IDs		K4PZ75 Q96NY8	Q15223
PDB IDs		4FRW 4GJT 4JJH	3ALP 3SKU 3U82 3U83 4FMF 4MYW
Enriched GO Terms of Interacting Partners?
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