TSEN2 and CADPS

Data Source:
BioGRID (two hybrid)

		TSEN2	CADPS
Description		tRNA splicing endonuclease subunit 2	calcium dependent secretion activator
Image		No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus Centrosome Cytosol	Cytosol Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Membrane
	Molecular Function	TRNA-intron Endonuclease Activity Nucleic Acid Binding Protein Binding Lyase Activity	Protein Binding Lipid Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Exocytosis Protein Transport Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Dense Core Granule Exocytosis
Pathways		tRNA processing in the nucleus
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Pontocerebellar hypoplasia
GWAS		Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Autism spectrum disorder ( 30804558) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast size ( 22747683 27182965) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Economic and political preferences (environmentalism) ( 22566634) Fasting plasma glucose ( 31932636) Hand grip strength ( 29691431) Lung function (FEV1/FVC) ( 30061609) Meat-related diet ( 32066663) Metabolite levels (X-11787) ( 23934736) Obsessive-compulsive symptoms ( 26859814) Optic disc size ( 31809533) Pre-treatment viral load in HIV-1 infection ( 31219150) Processed meat consumption ( 32066663) QT interval (sulfonylurea treatment interaction) ( 27958378) Risk-taking tendency (4-domain principal component model) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Trunk fat mass ( 28552196)
Interacting Genes		7 interacting genes: CADPS CTAG2 GABPB2 RANBP10 TAX1BP1 TEPSIN TSEN54	43 interacting genes: ACTN3 ANKS1A AURKC C17orf67 CABP5 CCDC120 CCDC185 DMD DNAJC5 DRD2 FAM161A FAM90A1 FAM9B FANCL FOXD2 GADD45GIP1 GPANK1 GSE1 HDAC4 HOXB5 HOXC8 KANK2 KIAA1549 LNX1 LUC7L2 OLIG3 PIP5K1A PNMA5 PRPF18 SDCBP SEC23A SH2D4A SHFL TCL1A TENT2 TRIM55 TRIM63 TSEN2 TTLL10 USP2 ZFC3H1 ZNF572 ZNF688
Entrez ID		80746	8618
HPRD ID		10576	05236
Ensembl ID		ENSG00000154743	ENSG00000163618
Uniprot IDs		A0A024R2G3 Q8NCE0	F1T0E5 Q9ULU8
PDB IDs			1WI1
Enriched GO Terms of Interacting Partners?
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