WDR61 and ERRFI1

Data Source:
BioGRID (two hybrid)

		WDR61	ERRFI1
Description		WD repeat domain 61	ERBB receptor feedback inhibitor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex	Nucleus Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of GTPase Activity Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Lung Vasculature Development Lung Epithelium Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Reticulocyte count ( 32888494)	Crohn's disease ( 28067908) Hair shape ( 29220522) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ	60 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 FYN GAS1 GNPDA2 GRB2 GTF2H2 HYDIN IL2RG MFSD5 MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WDR61 WEE1 YWHAB ZPBP
Entrez ID		80349	54206
HPRD ID		15236	09218
Ensembl ID		ENSG00000140395	ENSG00000116285
Uniprot IDs		H0YL19 Q9GZS3	B3KTV8 I6S2Y9 Q9UJM3
PDB IDs		3OW8 6GMH 6TED	2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV
Enriched GO Terms of Interacting Partners?
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