STN1 and TPP1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		STN1	TPP1
Description		STN1 subunit of CST complex	tripeptidyl peptidase 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton CST Complex	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation IRE1-mediated Unfolded Protein Response Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process
Pathways		Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation	XBP1(S) activates chaperone genes
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Chronic obstructive pulmonary disease ( 30804561) Leukocyte telomere length ( 32109421) Uterine fibroids ( 31488892 30194396) White matter integrity (mean diffusivity) ( 32358547)	Malaria ( 31844061)
Interacting Genes		19 interacting genes: APP C14orf119 C1orf109 CDK3 GOLGA2 LDLRAP1 LRRK2 MFHAS1 MKRN3 MVP NTAQ1 RCOR3 TEN1 TOLLIP TPP1 TRIML2 TUBGCP4 TXN2 ZDHHC17	6 interacting genes: CTC1 NMB POT1 STN1 TERT TINF2
Entrez ID		79991	1200
HPRD ID		14872	06415
Ensembl ID		ENSG00000107960	ENSG00000166340
Uniprot IDs		Q9H668	O14773
PDB IDs		4JOI 4JQF 6W6W	1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?
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