TLE6 and RPL14

Data Source:
BioGRID (two hybrid)

		TLE6	RPL14
Description		TLE family member 6, subcortical maternal complex member	ribosomal protein L14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cell Cortex Protein-containing Complex Subcortical Maternal Complex	Cytosol Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Actin Filament Organization Positive Regulation Of Embryonic Development Establishment Of Spindle Localization Regulation Of Cell Division Endoplasmic Reticulum Localization Mitochondrion Localization Embryonic Process Involved In Female Pregnancy Negative Regulation Of Canonical Wnt Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Ribosomal Large Subunit Biogenesis
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Artenimol
Diseases
GWAS			Neuroticism ( 29255261)
Interacting Genes		4 interacting genes: FOXG1 RIPK3 RPL14 TRIM54	7 interacting genes: FBXO7 KCNK4 KLF10 PEX5 PHLDA1 PTEN TLE6
Entrez ID		79816	9045
HPRD ID		18195	10617
Ensembl ID		ENSG00000104953	ENSG00000188846
Uniprot IDs		Q6PJM9 Q9H808	P50914
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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