AAGAB and AP2S1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology)

		AAGAB	AP2S1
Description		alpha and gamma adaptin binding protein	adaptor related protein complex 2 subunit sigma 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle
	Molecular Function	Protein Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Protein Transport	Intracellular Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Endocytosis Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Ephrin Receptor Signaling Pathway Clathrin Coat Assembly Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis
Pathways			Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Asthma ( 31959851 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bipolar disorder ( 31043756) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Proportion of activated microglia (midfrontal cortex) ( 30679421)	Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		9 interacting genes: AP1G1 AP1G2 AP1S3 AP2A1 AP2A2 AP2S1 EIF3C HEATR1 UNC119	6 interacting genes: AAGAB AP2A1 AP2B1 RNF41 TDGF1 UBC
Entrez ID		79719	1175
HPRD ID		07754	03762
Ensembl ID		ENSG00000103591	ENSG00000042753
Uniprot IDs		Q6PD74	M0QYZ2 M0R0N4 P53680 X6R390
PDB IDs			6URI
Enriched GO Terms of Interacting Partners?
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