LRRK1 and RAB29

Data Source:
BioGRID (pull down)

		LRRK1	RAB29
Description		leucine rich repeat kinase 1	RAB29, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Early Endosome Vacuole Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Endomembrane System Symbiont-containing Vacuole Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Kinesin Binding Small GTPase Binding Dynein Complex Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Receptor Recycling Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitochondrion Organization Golgi Organization Synapse Assembly Response To Bacterium Negative Regulation Of Neuron Projection Development Cell Differentiation Melanosome Organization Viral RNA Genome Replication T Cell Activation Retrograde Transport, Endosome To Golgi Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Intracellular Protein Transport Regulation Of Neuron Death Toxin Transport Protein Localization To Ciliary Membrane Regulation Of Retrograde Transport, Endosome To Golgi
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Central corneal thickness ( 32528159 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		51 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP VGLL4	8 interacting genes: BEND7 C11orf49 LDOC1 LRRK1 LSM7 REL TRIM27 TRIM32
Entrez ID		79705	8934
HPRD ID		14319	11962
Ensembl ID		ENSG00000154237	ENSG00000117280
Uniprot IDs		Q38SD2	B2R7I9 O14966 Q6FGU7
PDB IDs			6HH2
Enriched GO Terms of Interacting Partners?
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