SRD5A3 and ADK

Data Source:
BioGRID (two hybrid)

		SRD5A3	ADK
Description		steroid 5 alpha-reductase 3	adenosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity Polyprenol Reductase Activity	RNA Binding Adenosine Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichol Metabolic Process Dolichol Biosynthetic Process	Purine Ribonucleoside Salvage DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Phosphorylation Purine-containing Compound Salvage AMP Salvage
Pathways		Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ	Purine salvage
Drugs		Spironolactone	Adenosine phosphate 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Cardiac troponin-I levels ( 31014085) Diverticular disease ( 30177863) Drug experimentation measurement ( 30718321) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypospadias ( 25108383) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Permanent tooth development ( 21931568) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 30578418)
Interacting Genes		2 interacting genes: ADK NUDT15	2 interacting genes: FICD SRD5A3
Entrez ID		79644	132
HPRD ID		07825	00039
Ensembl ID		ENSG00000128039	ENSG00000156110
Uniprot IDs		Q9H8P0	A0A140VJE0 A0A5F9ZH72 A0A5F9ZHJ1 P55263
PDB IDs			1BX4 2I6A 2I6B 4O1L
Enriched GO Terms of Interacting Partners?
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