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GCC1 and BIRC2
Data Source:
BioGRID
(two hybrid, two hybrid)
GCC1
BIRC2
Description
GRIP and coiled-coil domain containing 1
baculoviral IAP repeat containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Trans Cisterna
Golgi Membrane
Golgi Apparatus
Cytosol
XY Body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Protein Binding
Small GTPase Binding
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Ubiquitin Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
FBXO Family Protein Binding
Biological Process
Protein Polyubiquitination
Response To Hypoxia
Placenta Development
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Regulation Of RIG-I Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Response To Ethanol
Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Regulation Of Inflammatory Response
Response To CAMP
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Necroptotic Process
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Protein K48-linked Ubiquitination
Positive Regulation Of Protein Monoubiquitination
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Retrograde transport at the Trans-Golgi-Network
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS
Feeling worry (
29500382
)
General cognitive ability (
29844566
)
Intelligence (MTAG) (
29326435
)
Medication adherence in chronic diseases (
25317111
)
Refractive error (
32231278
)
Type 2 diabetes (
26818947
22158537
30718926
)
Prostate cancer (
23535732
)
Interacting Genes
64 interacting genes:
ABI2
AMOTL2
APP
ARL1
ATF4
ATN1
BIRC2
BRCA1
C1orf94
CCDC33
CCDC85B
CEP57
CEP70
COIL
CPSF7
DISC1
DNAJA3
FAM83A
FBF1
FBXO28
FIGNL1
FOSL1
GAS8
GLI1
GOLGA2
GTF2I
HDX
ICA1L
IKBKG
ITSN1
KATNAL1
KDM1A
KIAA0753
KIAA1217
KIF5B
LCA5
LZTS2
MCRS1
MED4
MEOX1
MID2
NAB2
NAV1
NECAB2
NINL
OIP5
PAK5
PPP1R18
PPP1R27
PRPF18
RUNX1
SMARCD1
SPOP
TFIP11
TLE5
TP53BP2
TRIM29
TRIM50
USHBP1
UTP14C
XIAP
ZC4H2
ZFP90
ZNF276
75 interacting genes:
ABHD17A
BIRC5
BLK
BMX
BOLA1
BOLA2
BOLA2B
CASP3
CASP7
CASP9
CBLC
CD40
CDC42
CSE1L
DIABLO
DZIP3
E2F1
EAF2
EIF4E
EXOSC5
FBXO7
GAS1
GCC1
GFAP
GLMN
GSPT1
HSP90B1
HTRA2
IGF2BP1
IKBKE
IKBKG
JUP
KDM1A
LNX1
LTBR
MAD1L1
MAGEA11
MAP3K2
MAP3K3
NMB
NXF1
OTUB1
PACS2
PCSK9
PFN2
PPM1K
RAC1
RAF1
RFC5
RHOA
RIPK2
RIPK3
RIPK4
RNF181
RUNX1T1
TCAF1
TRADD
TRAF1
TRAF2
TRIM34
TSG101
TSGA10
TUFT1
UBB
UBC
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2J1
UBE2N
UBE2Q2
UBE2S
UBE2V1
UBE2W
Entrez ID
79571
329
HPRD ID
07599
03419
Ensembl ID
ENSG00000179562
ENSG00000110330
Uniprot IDs
A4D0Z4
Q96CN9
Q13490
PDB IDs
1QBH
2L9M
3D9T
3D9U
3M1D
3MUP
3OZ1
3T6P
3UW4
4EB9
4HY4
4HY5
4KMN
4LGE
4LGU
4MTI
4MU7
5M6N
6EXW
6HPR
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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