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BIRC7 and CASP9
Data Source:
HPRD
(in vivo)
BIRC7
CASP9
Description
baculoviral IAP repeat containing 7
caspase 9
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoplasm
Cytosol
Protein-containing Complex
Apoptosome
Molecular Function
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Enzyme Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Activator Activity
Peptidase Activity
SH3 Domain Binding
Protein Kinase Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Lens Development In Camera-type Eye
Apoptotic Process
Activation Of JUN Kinase Activity
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of Cell Cycle
Regulation Of Natural Killer Cell Apoptotic Process
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Platelet Formation
Cellular Response To UV
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Regulation Of Response To DNA Damage Stimulus
Pathways
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
Caspase activation via Dependence Receptors in the absence of ligand
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Drugs
Pamidronic acid
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Urate levels (
31578528
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Interacting Genes
37 interacting genes:
AURKC
BOLA1
BOLA2
BOLA2B
CASP3
CASP7
CASP9
DDX6
DIABLO
FAM124B
GTF2A1
HTRA2
KANK2
LCOR
LMO4
NTAQ1
PHF1
POLR1C
PRR35
PSMB1
PTCD3
QARS1
SOX5
TEPSIN
TLE5
TNPO2
TSGA10IP
TTPA
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2I
UBE2K
USP2
VPS37C
XAF1
47 interacting genes:
ABL1
AKT1
APAF1
ARNT
BCL10
BCL2L1
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BIRC8
CAPN2
CARD8
CASP10
CASP12
CASP3
CASP7
CASP8
CYCS
DCC
DIABLO
DSP
GMEB1
GZMB
HECTD3
HIP1
HSD17B4
HSPD1
ILK
JUN
LYN
MAP2K1
MAP2K2
MAPK1
MAPK3
MSTO1
MZB1
NAIP
NLRP1
NOD1
PRKCZ
RB1
RNF2
SRF
VIM
XIAP
Entrez ID
79444
842
HPRD ID
05761
03756
Ensembl ID
ENSG00000101197
ENSG00000132906
Uniprot IDs
Q96CA5
F8VVS7
P55211
PDB IDs
1OXN
1OXQ
1OY7
1TW6
2I3H
2I3I
3F7G
3F7H
3F7I
3GT9
3GTA
3UW5
4AUQ
1JXQ
1NW9
2AR9
3D9T
3V3K
3YGS
4RHW
5JUY
5WVC
5WVE
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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