ZIC1 and TSC1

Data Source:
BioGRID (two hybrid)

		ZIC1	TSC1
Description		Zic family member 1	TSC complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Central Nervous System Development Brain Development Regulation Of Smoothened Signaling Pathway Cell Differentiation Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of Transcription, DNA-templated	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways			Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		71 interacting genes: ABHD11 ANKRD10 ARID5A ATP23 BBS4 C11orf1 CDPF1 CRX CYSRT1 DAPL1 EEF1AKMT3 FAM168B FOXH1 GLI1 GLI2 GLI3 INTS11 KLHL26 KRT31 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LITAF MAGED1 METTL27 MGAT5B NFKBID OIP5 OXER1 PATZ1 PEF1 PLAAT1 PLSCR3 RBPMS REL RFC2 RNF144B RUSC1 SMAD4 SMUG1 SPAG8 SPATS1 SUFU TBX19 TEPSIN TLE5 TRAF1 TRIP6 TSC1 UBE2I UFSP1 WWOX YPEL3 ZNF34 ZNF474 ZNF620	99 interacting genes: AKT1 APPL2 AQP1 ARAF ARID5A ATXN1 AURKA BAG3 BECN1 C1orf94 CCDC120 CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CHCHD2 CSTF2 DMRT3 DOK5 ENKD1 EZR FAM110A FAM222B FGFR4 FOXH1 FRS3 GLIS2 GPANK1 HOXC8 HR HSH2D IGFN1 IKBKB KAT2A KDM1A LATS2 LENG1 LMO2 MAP2K5 MAPK14 MSN MYC MYLIP MYOZ3 NEFL NF2 PATL1 PATZ1 PITX1 PLK1 PLK2 POGZ POU6F2 PPP1R18 PPP1R32 PRMT6 RASSF1 RBPMS RDX RHEB RIN1 RIN3 SAMD11 SAMD7 SH2D2A SHC3 SMG9 SOX4 SPAG8 SUOX TBC1D7 TBX6 TCF7L2 TFAP2D TLE5 TNS2 TSC2 TSGA10IP TSHZ3 VENTX VEZF1 VGLL3 VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF587 ZNF765
Entrez ID		7545	7248
HPRD ID		02718	05594
Ensembl ID		ENSG00000152977	ENSG00000165699
Uniprot IDs		Q15915	A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs			4Z6Y 5EJC
Enriched GO Terms of Interacting Partners?
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