YWHAB and EPB41L1

Data Source:
HPRD (two hybrid)

		YWHAB	EPB41L1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	erythrocyte membrane protein band 4.1 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	MAPK Cascade Negative Regulation Of Protein Kinase Activity Protein Targeting Viral Process Negative Regulation Of Protein Dephosphorylation Hippo Signaling Positive Regulation Of Catalytic Activity Regulation Of MRNA Stability Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Sequestering Of Protein Membrane Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by MRAS-complex mutants	Trafficking of AMPA receptors Neurexins and neuroligins
Drugs		Copper Phenethyl Isothiocyanate
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)	Height ( 23563607) Hip circumference ( 25673412) Keratinocyte cancer (MTAG) ( 31174203) Refractive error ( 32231278)
Interacting Genes		142 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1	19 interacting genes: AGAP2 APP ARHGAP1 CHRM5 DRD2 DRD3 GRIA1 GRIA4 HSPB1 ITPR1 NR3C1 NUMA1 POT1 SRPK2 STARD13 TERF1 YWHAB YWHAQ YWHAZ
Entrez ID		7529	2036
HPRD ID		03184	04193
Ensembl ID		ENSG00000166913	ENSG00000088367
Uniprot IDs		P31946 V9HWD6	A0A0C4DH22 B7Z653 Q9H4G0
PDB IDs		2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP
Enriched GO Terms of Interacting Partners?
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