CORO2A and TBL1X

Data Source:
HPRD (in vitro)

		CORO2A	TBL1X
Description		coronin 2A	transducin beta like 1 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Repressor Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Protein Binding Actin Filament Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding
	Biological Process	Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS		Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)	Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: AURKA BUB1 DCC DLC1 HDAC3 NRAS RB1 SMAD2 TBL1X TBL1XR1 UBE2I	29 interacting genes: ARL3 CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I
Entrez ID		7464	6907
HPRD ID		03695	02183
Ensembl ID		ENSG00000106789	ENSG00000101849
Uniprot IDs		A0A024R150 A8K9S3 Q92828	A0A024RBV9 O60907
PDB IDs			2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?
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