EIF4H and DLG3

Data Source:
BioGRID (two hybrid)

		EIF4H	DLG3
Description		eukaryotic translation initiation factor 4H	discs large MAGUK scaffold protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding	Protein Binding Kinase Binding Phosphatase Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation Viral Process Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS			Mean platelet volume ( 32888494)
Interacting Genes		7 interacting genes: C11orf68 DDIT4L DLG3 FBXO17 LNX1 PICK1 SPG21	48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		7458	1741
HPRD ID		11940	02177
Ensembl ID		ENSG00000106682	ENSG00000082458
Uniprot IDs		Q15056	Q59FY1 Q92796
PDB IDs			1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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