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WAS and VASP
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro)
WAS
VASP
Description
WASP actin nucleation promoting factor
vasodilator stimulated phosphoprotein
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Site Of Double-strand Break
Phagocytic Vesicle
Extracellular Exosome
Cytosol
Plasma Membrane
Bicellular Tight Junction
Focal Adhesion
Actin Cytoskeleton
Lamellipodium Membrane
Filopodium Membrane
Extracellular Exosome
Molecular Function
Actin Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Regulator Activity
Small GTPase Binding
Identical Protein Binding
Phospholipase Binding
Actin Binding
Protein Binding
Profilin Binding
SH3 Domain Binding
Cadherin Binding
Biological Process
Regulation Of T Cell Antigen Processing And Presentation
Defense Response
Immune Response
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Actin Polymerization Or Depolymerization
Actin Polymerization Or Depolymerization
Epidermis Development
Regulation Of Lamellipodium Assembly
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Cdc42 Protein Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Protein-containing Complex Assembly
Cellular Response To Interferon-gamma
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Motility
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Neural Tube Closure
Axon Guidance
Actin Polymerization Or Depolymerization
Actin Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Cell Junction Assembly
Protein Homotetramerization
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Generation of second messenger molecules
Signaling by ROBO receptors
Signaling by ROBO receptors
Cell-extracellular matrix interactions
Drugs
(S)-wiskostatin
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Platelet distribution width (
32888494
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Interacting Genes
56 interacting genes:
ABI3
ACTC1
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CRKL
CSNK2A1
CSNK2A2
DLG1
DVL2
ENAH
EVL
FCHSD2
FGR
FYB1
FYN
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RANBP2
RGS14
RHOJ
SNX9
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
UBASH3A
VASP
WBP4
WIPF1
WIPF2
44 interacting genes:
ABI1
ABI2
ABI3
ACTA1
ACTG1
APBB1
APBB1IP
CDC42
CEP43
DMRTB1
DNMBP
ENAH
ERMAP
EVL
FAT1
FRS3
FYB1
GSN
IQGAP1
LPP
NOL3
NR4A1
PFN1
PFN2
PLSCR1
PRKACA
PRKG1
PRPF40A
PSORS1C2
RAD51
RAPH1
SAT1
SCGB2A2
SPTA1
TES
TRIM15
TRIM9
VCL
WAS
WASL
WWP2
XIRP1
XPO6
ZYX
Entrez ID
7454
7408
HPRD ID
02314
03415
Ensembl ID
ENSG00000015285
ENSG00000125753
Uniprot IDs
A0A024QYX8
P42768
A0A024R0V4
P50552
PDB IDs
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
1EGX
1JNG
1USD
1USE
2PAV
2PBD
3CHW
Enriched GO Terms of Interacting Partners
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