VAV1 and AOC3

Data Source:
HPRD (in vivo)

		VAV1	AOC3
Description		vav guanine nucleotide exchange factor 1	amine oxidase copper containing 3
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction	Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus Cell Surface Integral Component Of Membrane
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Metal Ion Binding Phosphorylation-dependent Protein Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Amine Oxidase Activity Identical Protein Binding Protein Heterodimerization Activity Quinone Binding Tryptamine:oxygen Oxidoreductase (deaminating) Activity Aminoacetone:oxygen Oxidoreductase(deaminating) Activity Aliphatic-amine Oxidase Activity Phenethylamine:oxygen Oxidoreductase (deaminating) Activity
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cytokine-mediated Signaling Pathway Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Reactive Oxygen Species Metabolic Process	Xenobiotic Metabolic Process Inflammatory Response Cell Adhesion Amine Metabolic Process Response To Antibiotic Negative Regulation Of Primary Amine Oxidase Activity
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Phase I - Functionalization of compounds
Drugs			Phenelzine Hydralazine 6-hydroxydopa quinone
Diseases
GWAS		Blood protein levels ( 30072576) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		79 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX	13 interacting genes: ARL13B CLDN9 CPLX4 CREB3L1 DARS2 FNDC9 HSD17B13 LMNA MYBPC2 PRRG4 SGTA STX1A VAV1
Entrez ID		7409	8639
HPRD ID		01284	04770
Ensembl ID		ENSG00000141968	ENSG00000131471
Uniprot IDs		A0A0A0MR07 B2R8B5 P15498 Q96D37	Q16853 Q9UEU7
PDB IDs		2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA	1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY
Enriched GO Terms of Interacting Partners?
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