CLRN1 and ALG8

Data Source:
BioGRID (two hybrid)

		CLRN1	ALG8
Description		clarin 1	ALG8 alpha-1,3-glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Microvillus Microtubule Cytoskeleton Integral Component Of Membrane Lamellipodium Trans-Golgi Network Transport Vesicle Stereocilium Basal Part Of Cell	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Actin Filament Organization Visual Perception Sensory Perception Of Sound Positive Regulation Of Lamellipodium Assembly Photoreceptor Cell Maintenance Cell Motility Response To Stimulus Sensory Perception Of Light Stimulus Equilibrioception Auditory Receptor Cell Stereocilium Organization	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs
Diseases		Usher syndrome (US)	Congenital disorders of glycosylation (CDG) type I
GWAS		Chronotype ( 30696823) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600)	Depression in smokers ( 30219690) Tourette syndrome ( 30818990)
Interacting Genes		28 interacting genes: ALG8 BRICD5 C2CD2L CANT1 CCL4L2 CLDN19 CTXN3 DRAM1 FAM24B FUT9 ITGAM MFSD5 MGST3 NRM SEC22B SLC34A3 TMEM140 TMEM147 TMEM222 TMEM239 TMEM31 TMEM50B TMEM86B TMIE TMPPE TMPRSS4 UNC50 ZDHHC15	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		7401	79053
HPRD ID		05905	10480
Ensembl ID		ENSG00000163646	ENSG00000159063
Uniprot IDs		P58418	A0A024R5K5 Q9BVK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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