UROD and PHKA2

Data Source:
BioGRID (two hybrid)

		UROD	PHKA2
Description		uroporphyrinogen decarboxylase	phosphorylase kinase regulatory subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cytosol Plasma Membrane Phosphorylase Kinase Complex
	Molecular Function	Uroporphyrinogen Decarboxylase Activity Protein Binding	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process	Carbohydrate Metabolic Process Glycogen Catabolic Process Generation Of Precursor Metabolites And Energy Cellular Protein Modification Process Protein Phosphorylation
Pathways		Heme biosynthesis	Glycogen breakdown (glycogenolysis)
Drugs		Coproporphyrin I Coproporphyrinogen III
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		10 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA TSSK3 VIM	5 interacting genes: PHKB PHKG2 RAF1 SMAD9 UROD
Entrez ID		7389	5256
HPRD ID		01441	02380
Ensembl ID		ENSG00000126088	ENSG00000044446
Uniprot IDs		P06132	P46019
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?
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